Main >> Imininingwane Yezidakamizwa >> Yini iSymbicort futhi isetshenziselwani?

Yini iSymbicort futhi isetshenziselwani?

Imininingwane Yezidakamizwa

Yini iSymbicort? | Isebenza kanjani | Imithamo | Imininingwane yezokuphepha | Ezinye izindlela ze-Symbicort

Abantu abaphila ne-asthma noma i-chronic obstructive pulmonary disease (COPD) banezinkinga zokuphefumula ezenza imisebenzi ejwayelekile ibe nzima noma icishe ingenzeki. Kaningi bazizwa sengathi baphefumula ngotshani noma sengathi banomoya omningi kakhulu obhajwe emaphashini abo. Lezi zinkinga zokuphefumula zivame ukubikezelwa.

I-Symbicort yenza ukuphefumula kube lula. Le inhaler isiza abantu abane-asthma noma i-COPD ukuthi babuyele emisebenzini yabo ejwayelekile yokuphila. Lo mhlahlandlela weSymbicort uzochaza ukuthi usebenza kanjani, uwusebenzisa kanjani ngokuphepha futhi uvikele imiphumela emibi, nokuthi uhlangana kanjani neminye imithi.

OKUSHIWO: Thola amakhuphoni we-Symbicort | Yini iSymbicort?

Yini iSymbicort, futhi isetshenziselwani?

I-Symbicort i-inhaler eyenziwe yi-AstraZeneca, futhi iqukethe izithako ezimbili. Eyodwa ibizwa ngokuthi i-budesonide, i-corticosteroid esebenza isikhathi eside esetshenziswayo esetshenziselwa ukunciphisa ukuvuvukala. Esinye isithako yi-formoterol, okuyi-beta-2 agonist (LABA) esebenza isikhathi eside esetshenziselwa ukuvula imigwaqo yomoya emaphashini. I-Symbicort yisidakamizwa esinegama lomkhiqizo. Uhlobo olujwayelekile lubizwa ngokuthi i-budesonide-formoterol. I-Symbicort kanye nohlobo lwayo olujwayelekile kutholakala kuphela ngemithi kadokotela.

Ngo-2006, i- Ukuphathwa Kwezokudla Nezidakamizwa (I-FDA) ivume i-Symbicort ekwelapheni i-asthma ezigulini ezineminyaka engu-12 nangaphezulu. I-FDA yavuma i-Symbicort ekwelapheni i-COPD ngo-2009. Muva nje, i-FDA igunyaze i-Symbicort njengokwelashwa kwesifuba somoya ezinganeni ezineminyaka eyisithupha kuya kwengu-12 ubudala.

I-Symbicort isetshenziswa njengokwelashwa kwesondlo se-asthma ne-COPD. Ngoba i-bronchodilator esebenza isikhathi eside, akufanele isetshenziswe njenge-inhaler yokutakula yokwanda kwe-COPD noma ukuhlaselwa yisifuba somoya (i-inhaler esebenza ngokushesha i-albuterol noma i-levalbuterol isetshenziselwa ukwelapha ukuhlaselwa yisifuba somoya). Esikhundleni salokho, i-Symbicort inhaler kufanele isetshenziswe ekuseni nakusihlwa ukusiza ukuphatha izimpawu.

Uphawu lwesifo somoya

Isifuba somoya (i-asthma) yisifo esingezwani nezinto ezithile. Abantu abane-asthma bayazwela ezintweni ezithile ezisemoyeni njengothuli, intuthu, noma idander. Lokhu kubangela ukungezwani komzimba okubonakala ngokucasuka nokuvuvukala kwemigwaqo yomoya yamaphaphu. Izindlela zomoya ziyancipha, okuholela ebuhlungwini besifuba, ukuphefumula okuncane, ukukhwehlela nokuphefumula. I-Symbicort isiza ekunciphiseni izimpawu zesifuba somoya ngokunciphisa ukuvuvukala nokwenza ukuthi izindlela zomoya zikhule futhi zihlale zivulekile. I-Symbicort inhaler isetshenziswa kabili ngosuku i-asthma. Ukusetshenziswa njalo kuzothuthukisa izimpawu eziyisisekelo zeziguli. Symbicort kuyinto hhayi i-inhaler yokutakula yokwelapha ukuhlaselwa yisifuba somoya. Kodwa-ke, ukuthatha iSymbicort njalo kudala ukuthi abantu benze babe nokuhlaselwa yisifuba somoya okumbalwa .

I-Symbicort inqunywa kuphela ngemuva kokuba iziguli zizame eminye imithi yesifo somoya. Imithi yokuqala odokotela abayinikezayo imvamisa albuterol . Uma lokho kungazilawuli izimpawu, umhlinzeki wezokunakekelwa kwempilo kungenzeka engeze i-corticosteroid (ICS) ethwala isikhashana esebenza kancane I-Flovent HFA (i-fluticasone) noma I-QVAR (beclomethasone) . Uma ukulawulwa kwesifuba somoya kungatholakali ngemithi emibili, udokotela angahle anikeze iSymbicort.

I-Symbicort ye-COPD

Isifo samaphaphu esingapheliyo sesinye isifo samaphaphu esivezwa yimigwaqo yomoya evuvukile neyonakele. I-COPD ihlukile kwesifuba somoya ngoba ukuvuvukala nokucasuka akubangelwa ukuzwela kwamagciwane. Esikhundleni salokho, kubangelwa ukuvezwa isikhathi eside kumakhemikhali acasulayo afana nentuthu kagwayi. Kunezinhlobo ezimbili ze-COPD: i-bronchitis engapheli ne-emphysema .

I-bronchitis engapheli iba lapho ulwelwesi lwamafinyila oluhambisana nemigwaqo yomoya (okuthiwa amashubhu we-bronchial) luvuvukala. Lokhu kubangela ukuthi kukhiqizwe amafinyila amaningi. Amashubhu we-bronchial agcwala amafinyila engeziwe, abangela ukuphefumula okuncane. I-bronchitis ibonakala ngokukhwehlela okuvame ukuletha amafinyila. Ngeza kulokho kuphefumula, umphimbo obuhlungu, kanye nezifo zokuphefumula ezibangelwa amagciwane.

I-Emphysema ibonakala ngezikhwama zomoya ezilimele emaphashini. Lezi zikhwama zomoya ngokujwayelekile zinwebeka njengebhaluni lapho amaphaphu agcwalisa umoya, abese encipha ukukhipha umoya emzimbeni. Kepha lapho la masaka elinyazwa yizinto ezicasulayo ezifana nentuthu kagwayi, zilahlekelwa ukwakheka kwazo nokunwebeka. Ngenxa yalokho, umoya awungeni kalula ngaphakathi nangaphandle kwamaphaphu. Abantu abane-emphysema babhekana nokuphefumula, isifuba nokukhwehlela okukhiqizayo.

I-Symbicort ilapha i-bronchitis ne-emphysema ngokunciphisa ukuvuvukala emaphashini nokuvula izindlela zomoya.

Ngaphambi kokusebenzisa iSymbicort ukwelapha i-COPD, odokotela babeka ezinye izindlela zokwelashwa ukubona ukuthi zizokwazi yini ukulawula izimpawu zesiguli. Ukwelashwa okuza ngaphambi kweSymbicort kungafaka I-Ventolin HFA (albuterol) , Inhlanganisela (i-albuterol ene-ipratropium) , I-Spiriva (tiotropium) , noma eminye imithi ehogelwayo. Uma isiguli sisenezimpawu eziya ziba zimbi, udokotela angahle anikeze iSymbicort.

Ngenkathi i-Symbicort ingasetshenziswanga ukwengeza ukukhushulwa kwe-COPD, iyasebenza ukunciphisa inani lokukhuphuka ezigulini ezithatha i-Symbicort 160/45 mcg kabili nsuku zonke.

Isebenza kanjani iSymbicort?

I-Symbicort inezithako ezimbili ezisebenzayo ezisebenza ngezindlela ezahlukene ukuvula imigwaqo yomoya. IBudesonide iyi-corticosteroid ehogelwe (ikakhulukazi, iyi- i-glucocorticoid) okunciphisa ukuvuvukala emaphashini. IFormoterol fumarate dihydrate iyi-beta-2 adrenergic agonist ebanga izinhlobo ezithile zemisipha ukuthi ziphumule.

Amashubhu alawula imisipha angenisa umoya emaphashini. La ma-tubes abizwa ngokuthi yi-bronchial airways. Lapho imisipha ekulemibhobho ingena, imigwaqo yomoya iba mincane. IFormoterol iyi-beta-agonist enamathela kulawa maseli emisipha, iwatshengisela ukuthi aphumule. Ngenxa yalokho, amashubhu aya ebanzi, avumela ukuhamba komoya okwengeziwe.

Ukuvuvukala kunganciphisa imigwaqo yomoya ngokwenza ukuvuvukala kwezindonga zethubhu. Izindiza ezivuvukile zinendawo encane lapho umoya ungahamba khona. Ngokwengeziwe, kukhona ulwelwesi lwamafinyila ezindongeni zamashubhu. Ukuvuvukala kubangela ukuthi ulwelwesi lwamafinyila lwenze amafinyila amaningi, avale izindlela zomoya. Ukuvuvukala kulimaza izicubu, futhi. Endabeni ye-emphysema, ukuvuvukala kulimaza amasaka omoya aze aguquke ngendlela engeyiyo futhi angabe eselula isikhathi eside kahle. Ngokujabulisayo, i-budesonide ne-formoterol zinciphisa ukuvuvukala ngokunciphisa ukusebenza kwama-molecule abandakanyeka ezindleleni zomzimba zokungezwani komzimba nezingavumi.

I-Symbicort iyaqhubeka nemiphumela yayo isikhathi eside ngemuva kokuhogela. Lokhu kudala inzuzo eqhubekayo ekusebenzeni kwamaphaphu. Iziguli ezithatha iSymbicort zibika ukuthuthuka ku- izimpawu eziyisisekelo zosuku nobusuku . Ucwaningo lukhombisile ukuthi iziguli ezithatha i-Symbicort zinama-COPD flare-ups ambalwa ngonyaka, kanye nokuhlaselwa yisifuba somoya okumbalwa ngonyaka.

Ungayithatha kanjani iSymbicort

I-Symbicort iza kudivayisi ebizwa nge-metered-dose inhaler. I-Symbicort inhaler ilingana nebhokisi lomuthi futhi iguqula umuthi ube yi-aerosol (inkungu) ehogelwayo.

Uma kungokokuqala usebenzisa i-Symbicort, noma uma ungakayisebenzisi i-Symbicort isikhashana, kufanele ukhokhele i-inhaler. Shake kahle imizuzwana emihlanu, bese ufafaza emoyeni, kude nobuso bakho. Shake bese ufafaza okwesibili. Manje i-inhaler yakho isilungisiwe futhi isilungele ukusetshenziswa.

Nyakazisa i-Symbicort inhaler ngaphambi kokusetshenziswa ngakunye.
Susa ikepisi bese uqinisekisa ukuthi okhulumela umlomo uhlanzekile.
Bese ukhipha umoya, ukhiphe umoya omningi ngaphandle kwamaphaphu ngangokunokwenzeka.
Ngebhokisana eliqondile, beka okokukhuluma phambi komlomo wakho, bese uphefumulela phezulu kancane nangaphansi ngomlomo wakho ngenkathi ucindezela ngokuqinile phansi phezulu kwekhabethe kanye.
Bamba umoya wakho imizuzwana emihlanu kuya kweyishumi, bese uphefumulela ngaphandle kancane. Gwema ukufafaza umuthi emehlweni akho.
Linda umzuzu owodwa kuya kwemibili ngaphambi kokuhogela ukuhogela kwesibili.
Phinda yonke inqubo, uqale ngokunyakazisa i-inhaler.
Ngemuva komthamo ngamunye, hlambulula umlomo wakho ngamanzi. Ungagwinyi amanzi. Lokhu kwenziwa ukuvimbela ukutheleleka komlomo ngomlomo njenge-thrush.

Kukhona isibali sedosi phezulu kwe-inhaler esizoba phuzi lapho i-inhaler inamanani amancane angaphansi kwama-20 asele. Phonsa i-inhaler yakho lapho isibali sedosi sifinyelela ku-zero noma sekuphele izinyanga ezintathu wavula isikhwama se-foil.

Gcina i-Symbicort ekamelweni lokushisa, kude nokushisa nokukhanya okuqondile. Gcina i-Symbicort inhaler ngomlomo phansi.

OKUSHIWO: Ungayisebenzisa i-inhaler ephelelwe yisikhathi?

Imithamo

I-Symbicort iza ngamandla amabili: 80/45 mcg, kanye ne-160 / 4.5 mcg. Udokotela uzonquma ukuthi yimaphi amandla we-Symbicort azowasebenzisela i-asthma ngokuya ngeminyaka yesiguli nobukhulu bezimpawu. Amandla aphezulu weSymbicort (160 / 4.5 mcg) ahlala esetshenziselwa i-COPD.

Umthamo wokulinganisa we-Symbicort uphafuza kabili ngosuku — ukukhipha kabili ekuseni kanye nokuhlwa okumbili. Okufanelekile, imithamo kufanele ithathwe ngamahora ayi-10 kuye kwayi-12 ngaphandle. Kuthatha amahora ayisishiyagalombili ukuthi umzimba ususe uhhafu womuthi ohlelweni lwakho, namahora angama-24 ukuqeda u-90% wawo. Ngakho-ke, uma ukhohlwa ukuthatha umthamo, mane weqe umthamo ongabanjwanga. Thatha umthamo olandelayo ngesikhathi esijwayelekile. Ungalokothi uthathe imithamo engaphezu kwemibili ngosuku.

I-Symbicort ngokuvamile isiza iziguli zesifuba somoya ukuthi ziphefumule kangcono kungakapheli imizuzu eyi-15 futhi isiza iziguli ze-COPD ziphefumule kangcono kungakapheli imizuzu emihlanu. Kungathatha amasonto amabili ngaphambi kokuba izimpawu zokuqala zithuthuke.

Ungayeki ukuthatha iSymbicort ngaphandle kokucela udokotela wakho. Ukumisa kungazelelwe iSymbicort kungahle kuholele ekungeneni kwe-adrenal, okungadala ukukhathala, ukulahlekelwa isifiso sokudla, ubuthakathaka bemisipha nokungakhululeki esiswini.

Imininingwane yokuphepha yeSymbicort

Imikhawulo

I-Symbicort ayilungele wonke umuntu. Iziguli ezikhulelwe noma ezincelisayo kufanele zibuze odokotela bazo ukuthi ngabe ukusebenzisa iSymbicort kufanelekile.

I-Symbicort ingahle ingalungeli iziguli ezine-osteoporosis, isifo senhliziyo, ukushaya kwenhliziyo okungajwayelekile, umfutho wegazi ophakeme, ukuqubuka, ushukela ophakeme wegazi, ukutheleleka okuvamile, izinkinga zamehlo ezifana ne-cataract noma i-glaucoma, noma iziguli ezinamasosha omzimba abuthakathaka.

I-Symbicort akufanele isetshenziswe ezigulini ezinokungazwani komzimba ne-budesonide noma i-formoterol. I-Budesonide iyisithako esisebenzayo kuma-inhalers Pulmicort nase-Entocort EC. I-Formoterol iyisithako esisebenzayo ku-Perforomist. I-Budesonide ne-formoterol nazo zingatholakala kwamanye ama-inhalers. Iziguli kufanele njalo zazise umhlinzeki wazo wezokunakekelwa kwempilo ngemithi eyaliwa yizidakamizwa.

I-Symbicort ingakhuphula ubungozi bokuphokwa yinkukhu noma isimungumungwane, ngakho-ke odokotela bangacela umlando wokugoma.

Imiphumela emibi ye-Symbicort

I-Symbicort ithuthukisa kakhulu ikhwalithi yempilo, ivumela iziguli eziningi ukuthi zibuyele emisebenzini eziyithandayo. Kepha njenganoma imuphi omunye umuthi, i-Symbicort ingadala ukusabela okungekuhle, nayo.

Imiphumela emibi kakhulu ye-Symbicort yile:

Iphunga eligijimayo noma eligcwele (sinusitis)
Umphimbo obuhlungu
Ubuhlungu bekhanda
Ukuhlungu obusemhlane
Umkhuhlane
Ukugaya ukudla
Khwehlela
Ukuthimula

Imiphumela emibi kakhulu ye-Symbicort ayijwayelekile kakhulu. Zingafaka:

Umfutho wegazi ophakeme
Ukushaya kwenhliziyo okungajwayelekile
I-Hyperglycemia (ushukela ophakeme wegazi)
I-glaucoma noma i-cataract
Ukucindezelwa kokukhula (uma kusetshenziswe isikhathi eside ezinganeni)
Ubuningi bamaminerali amathambo aphansi, angaholela ekuthambekeleni kwamathambo
Ukucindezeleka kokuphefumula njenge-bronchospasm, i-bronchitis, ukutheleleka kwamaphaphu, noma ukuhlaselwa yi-asthma

OKUSHIWO: Funda kabanzi ngemiphumela emibi ye-Symbicort

Ukusebenzisana kwezidakamizwa i-Symbicort

I-Symbicort ingaxhumana nemithi ethile esetshenziswayo ukwelapha umfutho wegazi ophakeme, waziwa ngo beta blocker . Banomphumela ophambene weSymbicort. Ukuthatha le mithi nge-Symbicort kungakhuphula ubungozi be-bronchospasm.

Ukuthatha i-Symbicort nge isisu njenge-furosemide noma i-hydrochlorothiazide ingakhuphula ubungozi be-potassium ephansi ( hypokalemia ).

Izidambisi ezithile zokulwa nokudangala izidakamizwa ezilwa nesigqi ingaxhumana ne-Symbicort, ibeka iziguli engcupheni enkulu yokuthola i-arrhythmia yenhliziyo eyingozi.

Imithi ye-HIV / AIDS kungakhuphula imiphumela ye-budesonide, kubeka iziguli engcupheni ye-Cushing's syndrome.

Imithi yokwelapha ukutheleleka kungakhuphula imiphumela ye-budesonide, kubeka iziguli engcupheni ye-Cushing's syndrome. Imithi yokwelapha efana ne-ketoconazole nayo ingakhuphula ingozi yesiguli yokuthola i-arrhythmia yenhliziyo eyingozi uma isetshenziswa ne-Symbicort.

Ezinye izindlela ze-Symbicort

I-AstraZeneca iphinde ikhiqize uhlobo olujwayelekile lwe-Symbicort, oluhamba ngegama elithi budesonide ne-formoterol dihydrate. Ngo-2020, i-FDA yavuma i-RPK Pharmaceuticals ukuthi nayo ikhiqize i-generic. Kusukela ngoMashi 2021, i-FDA inayo inikezwe imvume yesikhashana yeViatris Inc. neKindeva Drug Delivery L.P ukumaketha okujwayelekile. Lokhu kugunyazwa ukwandisa ukufinyelela okungabizi kulo muthi.

Bona ngezansi ukuthola ezinye izindlela zesifuba somoya futhi I-COPD asesigabeni esifanayo ne-Symbicort:

Qhathanisa ezinye izindlela
	Uhlobo lwedivayisi	Ukusetshenziswa okuvunyelwe	Imininingwane eminingi	Ukonga kwe-SingleCare
I-Advair Diskus (i-fluticasone-salmeterol)	I-inhaler eyomile yomswakama (DPI)	Isifo Somoya (i-4 yrs +), i-COPD	Funda kabanzi	Thola amakhuphoni
I-Advair HFA (i-fluticasone-salmeterol)	I-metered dose inhaler (MDI)	Isifo Somoya (i-12 yrs +)	Funda kabanzi	Thola amakhuphoni
I-Airduo Respiclick (i-fluticasone-salmeterol)	I-inhaler eyomile yomswakama (DPI)	Isifo Somoya (i-12 yrs +)	Funda kabanzi	Thola amakhuphoni
IBreo Ellipta (i-fluticasone-vilanterol)	I-inhaler eyomile yomswakama (DPI)	Isifo Somoya (i-18 yrs +), i-COPD	Funda kabanzi	Thola amakhuphoni
I-Dulera (mometasone-formoterol)	I-metered dose inhaler (MDI)	Isifo Somoya (i-12 yrs +)	Funda Okuningi	Thola ikhadi
I-Wixela Inhub (fluticasone-salmeterol)	I-inhaler eyomile yomswakama (DPI)	Isifo Somoya (i-4 yrs +), i-COPD	Funda kabanzi	Thola ikhadi